Browse by author
Lookup NU author(s): Dr Carmen Martin-RuizORCiD, Dr Aurora Gomez Duran, Professor Thomas von Zglinicki
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
This work investigates the association between longevity, mitochondrial DNA (mtDNA) variants and oxidative DNA damage in an older than 85 years population. The participants, similar in genetic and cultural background as well as gender distribution, come from villages near to the Pyrenees Mountains (900-1,400 m altitude) (n = 69) and the Ebro's Valley (200-300 m altitude) (n = 69) in Spain. Our results show an accumulation of the haplogroup J in elderly individuals with an over-representation of J2 in Pyrenees group but not in the Ebro's Valley, the former associating with a diminished DNA damage. In conclusion, our results suggest that J mitochondrial variant, that induce lower mtDNA damage, could present a phenotypic survival advantage to environmental conditions and, thus, accumulate in elderly population.
Author(s): Domínguez-Garrido E, Martínez-Redondo D, Martín-Ruiz C, Gómez-Durán A, Ruiz-Pesini E, Madero P, Tamparillas M, Montoya J, von Zglinicki T, Díez-Sánchez C, López-Pérez M
Publication type: Article
Publication status: Published
Journal: Biogerontology
Year: 2009
Volume: 10
Issue: 4
Pages: 435-442
ISSN (print): 1389-5729
ISSN (electronic): 1573-6768
Publisher: Springer
URL: http://dx.doi.org/10.1007/s10522-008-9186-y
DOI: 10.1007/s10522-008-9186-y
Altmetrics provided by Altmetric