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Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations

Lookup NU author(s): Dr Carmen Martin-RuizORCiD, Dr Aurora Gomez Duran, Professor Thomas von Zglinicki


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This work investigates the association between longevity, mitochondrial DNA (mtDNA) variants and oxidative DNA damage in an older than 85 years population. The participants, similar in genetic and cultural background as well as gender distribution, come from villages near to the Pyrenees Mountains (900-1,400 m altitude) (n = 69) and the Ebro's Valley (200-300 m altitude) (n = 69) in Spain. Our results show an accumulation of the haplogroup J in elderly individuals with an over-representation of J2 in Pyrenees group but not in the Ebro's Valley, the former associating with a diminished DNA damage. In conclusion, our results suggest that J mitochondrial variant, that induce lower mtDNA damage, could present a phenotypic survival advantage to environmental conditions and, thus, accumulate in elderly population.

Publication metadata

Author(s): Domínguez-Garrido E, Martínez-Redondo D, Martín-Ruiz C, Gómez-Durán A, Ruiz-Pesini E, Madero P, Tamparillas M, Montoya J, von Zglinicki T, Díez-Sánchez C, López-Pérez M

Publication type: Article

Publication status: Published

Journal: Biogerontology

Year: 2009

Volume: 10

Issue: 4

Pages: 435-442

ISSN (print): 1389-5729

ISSN (electronic): 1573-6768

Publisher: Springer


DOI: 10.1007/s10522-008-9186-y


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Funder referenceFunder name
Aragon General Goverment (Grupos Consolidados Group B33)
CIBER for Rare Diseases
FIS-PI07-0045Instituto de Salud Carlos III (ISCIII)
PI050647Instituto de Salud Carlos III (ISCIII)