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Review: Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua

Lookup NU author(s): Dr Gendie Lash, Professor Steve RobsonORCiD, Dr Judith Bulmer

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Abstract

Leukocytes comprise approximately 30-40% of decidual stromal cells in early human pregnancy. The major leukocyte component is the uterine natural killer (uNK) cells. Despite over 20 years of research the functional role of these cells in situ remains unknown although they have been proposed to play roles in immunotolerance, regulation of trophoblast invasion and remodeling of the spiral arteries. Herein we review the functional roles of this important decidual cell type. © 2010 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Lash G, Robson S, Bulmer J

Publication type: Article

Publication status: Published

Journal: Placenta

Year: 2010

Volume: 31

Issue: Supplement A

Pages: S87-S92

Print publication date: 12/01/2010

ISSN (print): 0143-4004

ISSN (electronic): 1532-3102

Publisher: Elsevier Ltd

URL: http://dx.doi.org/10.1016/j.placenta.2009.12.022

DOI: 10.1016/j.placenta.2009.12.022

Notes: Annual Meeting of the International Federation of Placenta Associations. Adelaide, Australia. 6-9 October 2009.

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