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Gene expression profiling for food safety assessment: Examples in potato and maize

Lookup NU author(s): Dr Peter van Dijk, Professor Carlo Leifert


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Since the mid 1990s, microarray analysis has become one of the few tools that can analyze the entire contents of a cell regarding a specific information type. Especially since the development of whole genome microarrays the technique can be considered truly holistic. Most DNA based microarrays are used for the analysis of the total of messenger RNAs (transcriptome) and provide a snap-shot of what's going on in a cell population at the time of sampling. Within the last few years also full genome plant microarrays have become available for several crop species. With these it has been shown that several growing conditions can be separated based on their transcriptome pattern, such as location, year of harvest and agricultural input system, but also different cultivars of the same crop species, including genetically modified ones. A database comprising expression levels of the transcriptome in many different circumstances with a history of safe use would be a good comparator for evaluation of new agricultural practices or cultivars, genetically modified or otherwise obtained. New techniques as next generation sequencing may overcome issues on throughput time and cost, standard operation procedures and array design for individual crops. (C) 2010 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): van Dijk JP, Leifert C, Barros E, Kok EJ

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Regulatory Toxicology and Pharmacology: Health and Environmental Sciences Institute Workshop on Evaluating Biological Variation in Non-Transgenic Crops

Year of Conference: 2010

Pages: S21-S25

ISSN: 0273-2300

Publisher: Academic Press


DOI: 10.1016/j.yrtph.2010.06.012

Library holdings: Search Newcastle University Library for this item

ISBN: 10960295