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Lookup NU author(s): Professor Marco Carrozzo
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BACKGROUND: Topical corticosteroids are the mainstay treatment for oral lichen planus (OLP), but some authors suggest that systemic corticosteroid therapy is the only way to control acute presentation of OLP. METHODS: Forty-nine patients with histologically proven atrophic-erosive OLP were divided into two groups matched for age and sex. The test group (26 patients) was treated systemically with prednisone (50 mg/day), and afterwards with clobetasol ointment in an adhesive medium plus antimicotics, whereas the control group (23 patients) was only treated topically with clobetasol plus antimycotics. RESULTS: Complete remission of signs was obtained in 68.2% of the test group and 69.6% of the control group, respectively (P = 0.94). Similar results were obtained for symptoms. Follow-up showed no significant differences between the two groups. One-third of the patients of the test group versus none in the control group experienced systemic side-effects (P = 0.003). CONCLUSIONS: The most suitable corticosteroid therapy in the management of OLP is the topical therapy, which is easier and more cost-effective than the systemic therapy followed by topical therapy.
Author(s): Carrozzo M; Carbone M; Goss E; Castellano S; Conrotto D; Broccoletti R; Gandolfo S
Publication type: Article
Publication status: Published
Journal: Journal of Oral Pathology & Medicine
Year: 2003
Volume: 32
Issue: 6
Pages: 323-329
ISSN (print): 0904-2512
ISSN (electronic): 1600-0714
Publisher: Wiley-Blackwell Publishing Ltd.
URL: http://dx.doi.org/10.1034/j.1600-0714.2003.00173.x
DOI: 10.1034/j.1600-0714.2003.00173.x
Notes: Clinical Trial Controlled Clinical Trial Journal Article
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