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Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long-term follow-up

Lookup NU author(s): Professor Marco Carrozzo


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BACKGROUND: Topical corticosteroids are the mainstay treatment for oral lichen planus (OLP), but some authors suggest that systemic corticosteroid therapy is the only way to control acute presentation of OLP. METHODS: Forty-nine patients with histologically proven atrophic-erosive OLP were divided into two groups matched for age and sex. The test group (26 patients) was treated systemically with prednisone (50 mg/day), and afterwards with clobetasol ointment in an adhesive medium plus antimicotics, whereas the control group (23 patients) was only treated topically with clobetasol plus antimycotics. RESULTS: Complete remission of signs was obtained in 68.2% of the test group and 69.6% of the control group, respectively (P = 0.94). Similar results were obtained for symptoms. Follow-up showed no significant differences between the two groups. One-third of the patients of the test group versus none in the control group experienced systemic side-effects (P = 0.003). CONCLUSIONS: The most suitable corticosteroid therapy in the management of OLP is the topical therapy, which is easier and more cost-effective than the systemic therapy followed by topical therapy.

Publication metadata

Author(s): Carrozzo M; Carbone M; Goss E; Castellano S; Conrotto D; Broccoletti R; Gandolfo S

Publication type: Article

Publication status: Published

Journal: Journal of Oral Pathology & Medicine

Year: 2003

Volume: 32

Issue: 6

Pages: 323-329

ISSN (print): 0904-2512

ISSN (electronic): 1600-0714

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1034/j.1600-0714.2003.00173.x

Notes: Clinical Trial Controlled Clinical Trial Journal Article


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