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Healing of tooth extraction sockets in the streptozotocin diabetic rat model: Induction of cartilage by BMP-6

Lookup NU author(s): Professor Philip Sloan

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Abstract

Cartilage does not form in the tooth extraction socket of the normal rat The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat

Publication metadata

Author(s): Shyng YC, Chi CY, Devlin H, Sloan P

Publication type: Article

Publication status: Published

Journal: Growth Factors

Year: 2010

Volume: 28

Issue: 6

Pages: 447-451

Print publication date: 01/12/2010

ISSN (print): 0897-7194

ISSN (electronic): 1026-7964

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.3109/8977194.2010.527966

DOI: 10.3109/8977194.2010.527966

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