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A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression

Lookup NU author(s): Dr Ahmad Khundakar, Dr Christopher Morris, Arthur Oakley, Professor Alan ThomasORCiD


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Background: The orbitofrontal cortex has been implicated as a key component in depression by several imaging studies. This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients. Methods: Post mortem tissue from 13 patients with major depression and 11 matched controls was obtained and analyzed using the optical disector and nucleator methods. Results: No changes were found in glial cell, pyramidal or non-pyramidal neuron density, or in non-pyramidal and pyramidal neuron volume in the orbitofrontal cortex. Conclusions: Based on previous findings, this study suggests variability in morphological changes within the orbitofrontal cortex, as well as the prefrontal cortex as a whole.

Publication metadata

Author(s): Khundakar A, Morris C, Oakley A, Thomas AJ

Publication type: Article

Publication status: Published

Journal: International Psychogeriatrics

Year: 2011

Volume: 23

Issue: 1

Pages: 132-140

Print publication date: 18/06/2010

ISSN (print): 1041-6102

ISSN (electronic): 1741-203X

Publisher: Cambridge University Press


DOI: 10.1017/S1041610210000700


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