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Lookup NU author(s): Dr Ahmad Khundakar,
Dr Christopher Morris,
Professor Alan ThomasORCiD
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Background: The orbitofrontal cortex has been implicated as a key component in depression by several imaging studies. This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients. Methods: Post mortem tissue from 13 patients with major depression and 11 matched controls was obtained and analyzed using the optical disector and nucleator methods. Results: No changes were found in glial cell, pyramidal or non-pyramidal neuron density, or in non-pyramidal and pyramidal neuron volume in the orbitofrontal cortex. Conclusions: Based on previous findings, this study suggests variability in morphological changes within the orbitofrontal cortex, as well as the prefrontal cortex as a whole.
Author(s): Khundakar A, Morris C, Oakley A, Thomas AJ
Publication type: Article
Publication status: Published
Journal: International Psychogeriatrics
Print publication date: 18/06/2010
ISSN (print): 1041-6102
ISSN (electronic): 1741-203X
Publisher: Cambridge University Press
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