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Biomimetic synthesis of collagen/nano-hydroxyapatite scaffold for tissue engineering

Lookup NU author(s): Dr Chaozong Liu

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Abstract

This paper reports a precipitation method for the fabrication of compositionally graded biomimetic collagen/nano-hydroxyapatite (HA) composite scaffold. The method is centrifugation based and produce the precipitation of nano-HA crystallites in situ (calcium ions (Ca2+) react phosphate ions (PO43−) and precipitate a non-stoichiometric hydroxyapatite). It was observed that prism needle-like nano-HA crystallites (about 2.5 nm × 3 nm× 25 nm) precipitated on collagen fibrils in the interior of collagen matrix. Chemical and microstructure analysis revealed a gradient of the Ca to P ratio across the width of the scaffold, lead to the formation of a HA-rich side and a HA-deplete side of scaffold. The HA-rich side featured low porosity and agglomerates of the nano-HA crystallites; while HA-depleted side featured higher porosity and nano-HA crystallites integrated with collagen fibrils to form a porous network structure.

Publication metadata

Author(s): Liu C

Publication type: Article

Publication status: Published

Journal: Journal of Bionic Engineering

Year: 2008

Volume: 5

Issue: S1

Pages: 1-8

ISSN (print): 1672-6529

Publisher: Science Press

URL: http://dx.doi.org/10.1016/S1672-6529(08)60064-5

DOI: 10.1016/S1672-6529(08)60064-5

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