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EMG prediction from motor cortical recordings via a Non-Negative Point Process Filter

Lookup NU author(s): Professor Kianoush Nazarpour



This is the final published version of an article that has been published in its final definitive form by IEEE, 2012.

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A constrained point process filtering mechanism for prediction of electromyogram (EMG) signals from multichannel neural spike recordings is proposed here. Filters from theKalman family are inherently sub-optimal in dealing with non-Gaussian observations, or a state evolution that deviates from the Markovian setting assumption. To address these limitations, we modeled the non-Gaussian neural spike train observations by using a generalized linear model (GLM) that encapsulates covariates of neural activity, including the neurons’ own spiking history, concurrent ensemble activity, and extrinsic covariates(EMG signals). In order to predict the envelopes of EMGs, we reformulated the Kalman filter (KF) in an optimization framework and utilized a non-negativity constraint. This structurecharacterizes the non-linear correspondence between neural activity and EMG signals reasonably. The EMGs were recorded from twelve forearm and hand muscles of a behaving monkey during a grip-force task. For the case of limited training data, the constrained point process filter improved the prediction accuracy when compared to a conventional Wiener cascade filter (a linear causal filter followed by a static non-linearity). The approach was tested for different bin sizes and delays between input spikes and EMG output; 20 ms bin size and 40 ms delay provided the highest prediction rates. For longer training data sets, results of the proposed filter and that of the Wiener cascade filter were comparable.

Publication metadata

Author(s): Nazarpour K, Ethier C, Paninski L, Rebesco JM, Miall RC, Miller LE

Publication type: Article

Publication status: Published

Journal: IEEE Transactions Biomedical Engineering

Year: 2012

Volume: 59

Issue: 7

Pages: 1829-1838

Print publication date: 09/06/2011

Date deposited: 11/07/2014

ISSN (print): 0018-9294

ISSN (electronic): 1558-2531

Publisher: IEEE


DOI: 10.1109/TBME.2011.2159115


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Funder referenceFunder name
Fonds de la Recherche en Sante du Quebec
National Science Foundation CAREER award
Searle Foundation through the Chicago Community Trust
Wellcome Trust, U.K.
F31NS062552National Institute of Neurological Disorders and Stroke (NINDS)
NS053603National Institute of Neurological Disorders and Stroke (NINDS)