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Orchestrating ribosomal activity from inside: effects of the nascent chain on the peptidyltransferase centre

Lookup NU author(s): Fu Yan, Dr Victoriya Doronina, Pamila Sharma, Dr Jeremy Brown


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Ribosomal progression through the open reading frames within mRNAs is frequently considered as uneventful when compared with the highly regulated initiation step However both RNA and nascent peptide can interact with the ribosome to influence how translation proceeds and can modify gene expression in several ways 2A peptides are a class of sequences that as nascent chains pause ribosomes and drive a translation termination reaction on a sense (proline) codon followed by continued downstream translation In the present paper what is known about the 2A reaction is discussed and 2A is compared with other sequences that as nascent peptides pause or stall translation

Publication metadata

Author(s): Yan F, Doronina VA, Sharma P, Brown JD

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2010

Volume: 38

Pages: 1576-1580

Print publication date: 01/12/2010

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.


DOI: 10.1042/BST0381576


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Funder referenceFunder name
Medial Research Council
Universities UK
Newcastle University
BB/E009093Biotechnology and Biological Sciences Research Council
C20418Biotechnology and Biological Sciences Research Council