Toggle Main Menu Toggle Search

Open Access padlockePrints

A homeodomain transcription factor regulates the DNA replication checkpoint in yeast

Lookup NU author(s): Frances Purtill, Dr Simon Whitehall, Professor Brian Morgan


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Checkpoints monitor the successful completion of cell cycle processes, such as DNA replication, and also regulate the expression of cell cycle-dependent genes that are required for responses. In the model yeast Schizosaccharomyces pombe G(1)/S phase-specific gene expression is regulated by the MBF (also known as DSC1) transcription factor complex and is also activated by the mammalian ATM/ATR-related Rad3 DNA replication checkpoint. Here, we show that the Yox1 homeodomain transcription factor acts to co-ordinate the expression of MBF-regulated genes during the cell division cycle. Moreover, our data suggests that Yox1 is inactivated by the Rad3 DNA replication checkpoint via phosphorylation by the conserved Cds1 checkpoint kinase. Collectively, our data has implications for understanding the mechanisms underlying the coordination of cell cycle processes in eukaryotes.

Publication metadata

Author(s): Purtill FS, Whitehall SK, Williams ES, McInerny CJ, Sharrocks AD, Morgan BA

Publication type: Article

Publication status: Published

Journal: Cell Cycle

Year: 2011

Volume: 10

Issue: 4

Pages: 664-670

Print publication date: 15/02/2011

ISSN (print): 1538-4101

ISSN (electronic): 1551-4005

Publisher: Landes Bioscience


DOI: 10.4161/cc.10.4.14824


Altmetrics provided by Altmetric