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Lookup NU author(s): Dr Ben Brilot,
Professor Melissa Bateson
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Cognitive bias is a phenomenon that presents in clinical populations where anxious individuals tend to adopt a more pessimistic-like interpretation of ambiguous aversive stimuli whereas depressed individuals tend to adopt a less optimistic-like interpretation of ambiguous appetitive stimuli. To further validate the chick anxiety-depression model as a neuropsychiatric simulation we sought to quantify this cognitive endophenotype. Chicks exposed to an isolation stressor of 5 m to induce an anxiety-like or 60 m to induce a depressive-like state were then tested in a straight alley maze to a series of morphed ambiguous appetitive (chick silhouette) to aversive (owl silhouette) cues. In non-isolated controls, runway start and goal latencies generally increased as a function of greater amounts of aversive characteristics in the cues. In chicks in the anxiety-like state, runway latencies were increased to aversive ambiguous cues, reflecting more pessimistic-like behavior. In chicks in the depression-like state, runway latencies were increased to both aversive and appetitive ambiguous cues, reflecting more pessimistic-like and less optimistic-like behavior, respectively. (c) 2010 Elsevier B.V. All rights reserved.
Author(s): Salmeto AL, Hymel KA, Carpenter EC, Brilot BO, Bateson M, Sufka KJ
Publication type: Article
Publication status: Published
Journal: Brain Research
Print publication date: 01/02/2011
ISSN (print): 0006-8993
ISSN (electronic): 1872-6240
Publisher: Elsevier BV
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