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Results of a Two-Center Study Comparing Hepatic Fibrosis Progression in HCV-positive Liver Transplant Patients Receiving Cyclosporine or Tacrolimus

Lookup NU author(s): Dr Mark Hudson, Professor Stuart McPhersonORCiD, Professor Alastair BurtORCiD, Professor Margaret Bassendine


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A 2-center retrospective analysis was performed in 60 patients undergoing liver transplantation for hepatitis C virus (HCV)-related disease (cyclosporine in 20, tacrolimus in 40). Mean (+/- SEM) follow-up was 23.6 +/- 22.5 and 22.3 +/- 13.7 months in patients receiving cyclosporine or tacrolimus, respectively. Clinically indicated biopsies were performed in 15/20 cyclosporine patients (75%) and 22/40 tacrolimus patients (55%; P = .17). The Ishak fibrosis score was significantly lower in cyclosporine-treated patients versus tacrolimus-treated patients (mean 1.7 +/- 0.4 vs 3.1 +/- 0.4; P = .023), as was percentage of fibrosis grade Ishak >= 4 (7% vs 41%; P = .028). The mean time to moderate fibrosis (Ishak score >= 3) was 38.2 +/- 15.1 months in cyclosporine patients (4/15) and 23.5 +/- 12.6 months in tacrolimus patients (14/22); the difference was not statistically significant (P = .09). This retrospective study suggests that cyclosporine-based immunosuppression is associated with less severe hepatic fibrosis in HCV-positive liver transplant recipients compared with tacrolimus-based regimens, but a larger prospective comparative trial is necessary to confirm these findings.

Publication metadata

Author(s): van der Laan LJW, Hudson M, McPherson S, Zondervan PE, Thomas RC, Kwekkeboom J, Lindsay AS, Burt AD, Kazemier G, Tilanus HW, Bassendine MF, Metselaar HJ

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Transplantation Proceedings: 23rd International Congress of the Transplantation Society

Year of Conference: 2010

Pages: 4573-4577

ISSN: 0041-1345

Publisher: Elsevier Inc.


DOI: 10.1016/j.transproceed.2010.10.013

Library holdings: Search Newcastle University Library for this item

ISBN: 18732623