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Examination of glucose transporter-1, transforming growth factor-β and neuroglobin immunoreactivity in the orbitofrontal cortex in late-life depression.

Lookup NU author(s): Dr Ahmad Khundakar, Louise Ward, Janet Slade, Professor Alan ThomasORCiD


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Aims: This study immunohistochemically examined the orbitofrontal cortex for three possible candidates in hypoxic/ischemic signaling: the cytokine transforming growth factor-β, the glucose transporter-1 and the neuron-specific oxygen-binding protein neuroglobin. Methods: Post-mortem tissue from 20 depressed and 20 non-depressed individuals was obtained and the expression of the three proteins was analyzed using image analysis software. Results: No significant changes were found in transforming growth factor-β or neuroglobin in the orbitofrontal cortex between depressed and non-depressed individuals. There was, however, a trend towards a reduction in glucose transporter-1 in the depressed group. Conclusions: This study does not clearly support the hypothesis that hypoxic/ischemic processes are behind the pathological deficits in the frontal-subcortical circuitry associated with depression and therefore does not provide evidence to support the 'vascular depression' hypothesis.

Publication metadata

Author(s): Khundakar A, Morris C, Slade J, Thomas AJ

Publication type: Article

Publication status: Published

Journal: Psychiatry and Clinical Neuroscience

Year: 2011

Volume: 65

Issue: 2

Pages: 158-164

Print publication date: 14/01/2011

ISSN (print): 1323-1316

ISSN (electronic): 1440-1819

Publisher: Wiley-Blackwell Publishing Asia


DOI: 10.1111/j.1440-1819.2010.02176.x

PubMed id: 21232076


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