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Lookup NU author(s): Dr Darroch Hall,
Dr Thahira Rahman,
Dr Peter Avery,
Professor Bernard Keavney
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Aims Genetic variation in the fatty acid translocase (CD36) gene has been shown in animal models to affect several risk factors for the development of left-ventricular hypertrophy, but this phenotype has not, thus far, been investigated in humans. We examined the relationship between common genetic polymorphisms in the CD36 gene and left-ventricular mass. Methods and results We studied a cohort of 255 families comprising 1425 individuals ascertained via a hypertensive proband. Seven single-nucleotide polymorphisms which together tagged common genetic variation in the CD36 gene were genotyped using a SEQUENOM MALDI-TOF instrument. There was evidence of association between the rs1761663 polymorphism in intron 1 of the CD36 gene and left-ventricular mass determined either by echocardiography (P=0.003, N=780) or electrocardiography (P=0.001, N=814). There was also association between rs1761663 genotype and body mass index (P < 0.001, N=1354). Genotype was associated with between 2 and 8% differences in these phenotypes per allele. After adjustment for the effect of body mass index, there remained significant associations between genotype and left ventricular mass measured either by echo (P=0.017) or ECG (P=0.007). Conclusions Genotype at the rs1761663 polymorphism has independent effects both on body mass index and left-ventricular mass. Genes with such pleiotropic effects may be particularly attractive therapeutic targets for interventions to modify multiple risk factors for cardiovascular events. J Hypertens 29:690-695 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Author(s): Hall D, Mayosi BM, Rahman TJ, Avery PJ, Watkins HC, Keavney B
Publication type: Article
Publication status: Published
Journal: Journal of Hypertension
Print publication date: 01/04/2011
ISSN (print): 0263-6352
ISSN (electronic): 1473-5598
Publisher: Lippincott Williams & Wilkins
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