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Lookup NU author(s): Dr Michail Karavolos,
Dr David Bulmer,
Dr Joseph Gray,
Dr Anjam Khan
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Salmonella enterica serovar Typhi ( S. typhi) causes typhoid fever. We show that exposure of S. typhi to neuroendocrine stress hormones results in haemolysis, which is associated with the release of haemolysin E in membrane vesicles. This effect is attributed to increased expression of the small RNA micA and RNA chaperone Hfq, with concomitant downregulation of outer membrane protein A. Deletion of micA or the two-component signal-transduction system, CpxAR, abolishes the phenotype. The hormone response is inhibited by the beta-blocker propranolol. We provide mechanistic insights into the basis of neuroendocrine hormone-mediated haemolysis by S. typhi, increasing our understanding of inter-kingdom signalling.
Author(s): Karavolos MH, Bulmer D, Spencer H, Rampioni G, Schmalen I, Baker S, Pickard D, Gray J, Fookes M, Winzer K, Ivens A, Dougan G, Williams P, Khan CMA
Publication type: Article
Publication status: Published
Journal: EMBO Reports
Print publication date: 18/02/2011
ISSN (print): 1469-221X
ISSN (electronic): 1469-3178
Publisher: Nature Publishing Group
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