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Flexible, all-polymer microelectrode arrays for the capture of cardiac and neuronal signals

Lookup NU author(s): Professor Evelyne SernagorORCiD


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Microelectrode electrophysiology has become a widespread technique for the extracellular recording of bioelectrical signals. To date, electrodes are made of metals or inorganic semiconductors, or hybrids thereof. We demonstrate that these traditional conductors can be completely substituted by highly flexible electroconductive polymers. Pursuing a two-level replica-forming strategy, conductive areas for electrodes, leads and contact pads are defined as microchannels in poly(dimethylsiloxane) (PDMS) as a plastic carrier and track insulation material. These channels are coated by films of organic conductors such as polystyrenesulfonate-doped poly(3,4-ethylenedioxy-thiophene) (PEDOT:PSS) or filled with a graphite-PDMS (gPDMS) composite, either alone or in combination. The bendable, somewhat stretchable, non-cytotoxic and biostable all-polymer microelectrode arrays (polyMEAs) with a thickness below 500 mu m and up to 60 electrodes reliably capture action potentials (APs) and local field potentials (LFPs) from acute preparations of heart muscle cells and retinal whole mounts, in vivo epicortical and epidural recordings as well as during long-term in vitro recordings from cortico-hippocampal co-cultures. (C) 2010 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Blau A, Murr A, Wolff S, Sernagor E, Medini P, Iurilli G, Ziegler C, Benfenati F

Publication type: Article

Publication status: Published

Journal: Biomaterials

Year: 2011

Volume: 32

Issue: 7

Pages: 1778-1786

Print publication date: 09/12/2010

ISSN (print): 0142-9612

ISSN (electronic): 1878-5905

Publisher: Elsevier BV


DOI: 10.1016/j.biomaterials.2010.11.014


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