Toggle Main Menu Toggle Search

Open Access padlockePrints

Clinical characteristics of mephedrone toxicity reported to the UK National Poisons Information Service

Lookup NU author(s): Professor Simon Thomas

Downloads


Abstract

Objective To describe the patterns and clinical features of toxicity related to recreational use of mephedrone and other cathinones in the UK using data collected by the National Poisons Information Service (NPIS). Methods The number of accesses to TOXBASE, the NPIS online poisons information database, details of consecutive cases uploaded onto TOXBASE and the number and details of telephone enquiries made to the NPIS by health professionals in the UK were collected for the period March 2009 to February 2010. Results Over the year of study there were 2901 TOXBASE accesses and 188 telephone enquiries relating to cathinones, the majority relating to mephedrone (TOXBASE 1664, telephone 157), with a month-on-month increase in numbers. In 131 telephone enquiries concerning mephedrone, alone or in combination with alcohol, common clinical features reported included agitation or aggression (n=32, 24%, 95% CI 18% to 33%), tachycardia (n=29, 22%, 95% CI 16% to 30%), confusion or psychosis (n=18, 14%, 95% CI 9% to 21%), chest pain (n=17, 13%, 95% CI 8% to 20%), nausea (n=15, 11%, 95% CI 7% to 18%), palpitations (n=14, 11%, 95% CI 6% to 18%), peripheral vasoconstriction (n=10, 8%, 95% CI 4% to 14%) and headache (n=7, 5%, 95% CI 2% to 11%). Convulsions were reported in four cases (3%, 95% CI 1% to 8%). One exposed person died following cardiac arrest (1%, 95% CI 0% to 4%), although subsequent investigation suggested that mephedrone was not responsible. Conclusions Toxicity associated with recreational mephedrone use is increasingly common in the UK. Sympathomimetic adverse effects are common and severe effects are also reported. Structured data collected by the NPIS may be of use in identifying trends in poisoning and in establishing toxidromes for new drugs of abuse.


Publication metadata

Author(s): James D, Adams RD, Spears R, Cooper G, Lupton DJ, Thompson JP, Thomas SHL

Publication type: Article

Publication status: Published

Journal: Emergency Medical Journal

Year: 2011

Volume: 28

Pages: 686-689

Print publication date: 25/08/2010

Date deposited: 07/02/2013

ISSN (print): 1472-0205

ISSN (electronic): 1472-0213

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/emj.2010.096636

DOI: 10.1136/emj.2010.096636


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share