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Lookup NU author(s): Dr Ling Juan Wu
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In bacteria, chromosome segregation and DNA replication occur concurrently and there is no clear equivalent of a eukaryote mitotic spindle. Chromosome segregation can be viewed as a two-step process. As the first step, the origin of replication regions are segregated actively, probably by a mechanism involving an as yet unidentified motor protein or proteins, and held in position. The second step is the separation and migration of the rest of the chromosome probably driven by forces generated from various cellular processes such as DNA replication, transcription and transertion.
Author(s): Wu LJ
Publication type: Article
Publication status: Published
Journal: Current Opinion in Genetics & Development
ISSN (print): 0959-437X
ISSN (electronic): 1879-0380
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