Toggle Main Menu Toggle Search

Open Access padlockePrints

Inflammation in Alzheimer's disease: Relevance to pathogenesis and therapy

Lookup NU author(s): Professor Raj KalariaORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Evidence for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease (AD) has been documented for a long time. However, the inflammation hypothesis in relation to AD pathology has emerged relatively recently. Even in this hypothesis, the inflammatory reaction is still considered to be a downstream effect of the accumulated proteins (amyloid beta (A) and tau). This review aims to highlight the importance of the immune processes involved in AD pathogenesis based on the outcomes of the two major inflammation-relevant treatment strategies against AD developed and tested to date in animal studies and human clinical trials - the use of anti-inflammatory drugs and immunisation against A. © 2010 BioMed Central Ltd.

Publication metadata

Author(s): Zotova E, Nicoll J, Kalaria R, Holmes C, Boche D

Publication type: Review

Publication status: Published

Journal: Alzheimer's Research and Therapy

Year: 2010

Volume: 2

Issue: 1

Pages: alzrt24

Print publication date: 01/01/2010

ISSN (electronic): 1758-9193


DOI: 10.1186/alzrt24