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Lookup NU author(s): Professor David Barer
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Background: Stroke patients are more likely to make a good recovery if they receive care in a well-organised stroke unit. However, there are uncertainties about how best to provide such care. We studied 2 key aspects of early stroke unit care: early active mobilisation (EM) and automated monitoring (AM) for physiological complications such as hypoxia. Methods: This was an observer-blinded, factorial (2 × 2) pilot randomised controlled trial recruiting stroke patients within 36 h of symptom onset. The patients were randomised to 1 of 4 nurse-led treatment protocols: (a) standard stroke unit care, (b) EM, (c) AM or (d) combined EM and AM. The primary outcome was the Rankin score at 3 months. We also report the data on feasibility and safety. Results: We randomised 32 patients (mean age = 65 years; mean baseline modified NIH score = 6). On unadjusted comparisons, the EM patients were significantly (p < 0.05) more likely to mobilise very early (within 1 h of randomisation) and to achieve walking by day 5 and were less likely to develop complications of immobility. The AM group was significantly (p < 0.05) more likely to have pre-defined physiological complication events detected. All these associations remained, but were less statistically significant, after correcting for age, baseline NIH score and co-interventions. There were no significant safety concerns. Discussion: We have demonstrated the feasibility of implementing EM and AM for physiological complications in a randomised controlled trial. Larger trials are warranted to determine whether these interventions have clinical benefits. Copyright © 2010 S. Karger AG, Basel.
Author(s): Langhorne P, Stott D, Knight A, Bernhardt J, Barer D, Watkins C
Publication type: Article
Publication status: Published
Journal: Cerebrovascular Diseases
Year: 2010
Volume: 29
Issue: 4
Pages: 352-360
Print publication date: 30/01/2010
ISSN (print): 1015-9770
ISSN (electronic): 1421-9786
Publisher: S. Karger AG
URL: http://dx.doi.org/10.1159/000278931
DOI: 10.1159/000278931
PubMed id: 20130401
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