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Autologous hematopoietic stem cell transplantation for childhood autoimmune disease

Lookup NU author(s): Dr Mario Abinun

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Abstract

Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) can be used in the management of patients with autoimmune disorders. Experience gained in adults has helped to better define the conditioning regimens required and appropriate selection of patients who are most likely to benefit from autologous HSCT. The field has been shifting toward the use of safer and less intense nonmyeloablative regimens used earlier in the disease course before patients accumulate extensive irreversible organ damage. This article reviews the experience of using autologous HSCT in treating the most common childhood autoimmune and rheumatic diseases, primarily juvenile idiopathic arthritis, systemic lupus erythematosus, and diabetes mellitus. © 2010 Elsevier Inc.

Publication metadata

Author(s): Milanetti F, Abinun M, Voltarelli J, Burt R

Publication type: Review

Publication status: Published

Journal: Pediatric Clinics of North America

Year: 2010

Volume: 57

Issue: 1

Pages: 239-271

Print publication date: 01/02/2010

ISSN (print): 0031-3955

ISSN (electronic): 1557-8240

URL: http://dx.doi.org/10.1016/j.pcl.2009.12.003

DOI: 10.1016/j.pcl.2009.12.003

PubMed id: 20307720

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