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Lookup NU author(s): Dr Mario Abinun
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Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) can be used in the management of patients with autoimmune disorders. Experience gained in adults has helped to better define the conditioning regimens required and appropriate selection of patients who are most likely to benefit from autologous HSCT. The field has been shifting toward the use of safer and less intense nonmyeloablative regimens used earlier in the disease course before patients accumulate extensive irreversible organ damage. This article reviews the experience of using autologous HSCT in treating the most common childhood autoimmune and rheumatic diseases, primarily juvenile idiopathic arthritis, systemic lupus erythematosus, and diabetes mellitus. © 2010 Elsevier Inc.
Author(s): Milanetti F, Abinun M, Voltarelli J, Burt R
Publication type: Review
Publication status: Published
Journal: Pediatric Clinics of North America
Print publication date: 01/02/2010
ISSN (print): 0031-3955
ISSN (electronic): 1557-8240
PubMed id: 20307720