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Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia

Lookup NU author(s): Dr Gerd Flodgren


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Epidemiological research provides strong evidence for a link between repetitive work (RW) and the development of chronic trapezius myalgia (TM). The aims were to further elucidate if an accumulation of sensitising substances or impaired oxygenation is evident in painful muscles during RW. Females with TM (n=14) were studied during rest, 30 minutes RW and 60 minutes recovery. Microdialysate samples were obtained to determine changes in intramuscular microdialysate (IMMD) [glutamate], [PG E 2 ], [lactate], and [pyruvate] (i.e., [concentration]) relative to work. Muscle oxygenation (St O 2) was assessed using near-infrared spectroscopy. During work, all investigated substances, except PG E 2, increased significantly: [glutamate] (54, P<.0001), [lactate] (26, P<.005), [pyruvate] (19, P<.0001), while the St O 2 decreased (P<.05). During recovery [PG E 2 ] decreased (P<.005), [lactate] remained increased (P<.001), [pyruvate] increased progressively (P<.0001), and St O 2 had returned to baseline. Changes in substance concentrations and oxygenation in response to work indicate normal increase in metabolism but no ongoing inflammation in subjects with TM. Copyright © 2010 Gerd M. Flodgren et al.

Publication metadata

Author(s): Flodgren G, Crenshaw A, Hellström F, Fahlström M

Publication type: Article

Publication status: Published

Journal: Journal of Biomedicine and Biotechnology

Year: 2010

Print publication date: 01/01/2010

ISSN (print): 1110-7243

ISSN (electronic): 1110-7251

Publisher: Hindawi Publishing Corporation


DOI: 10.1155/2010/513803

PubMed id: 20625491


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Funder referenceFunder name
510240Swedish Agency for Innovation Systems, VINNOVA