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Quality-of-life considerations in treatment of unresectable, recurrent head and neck cancer

Lookup NU author(s): Dr Charles Kelly, Professor Vinidh Paleri


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Recurrent, unresectable head and neck squamous cancer is a complex problem. Evidence for the efficacy of treatment is scant in this area and given the large number of patient and tumor variables involved in the recurrent tumor, several factors play a role in deciding the choice of management. The results of treatment are very poor and associated with significant toxicity. Thus, the quality of life outcome following treatment should play a major role in the choice of treatment. Unfortunately, generation of quality-of-life data is hampered by several factors, not least of which are the ethical issues raised by end of life care. This article reviews the relevant literature, summarizes existing evidence and draws conclusions, identifies gaps in the knowledge and offers guidance for further research. © 2010 Expert Reviews Ltd.

Publication metadata

Author(s): McLarnon C, Kulloo P, Mehanna H, Kelly C, Paleri V

Publication type: Review

Publication status: Published

Journal: Expert Review of Anticancer Therapy

Year: 2010

Volume: 10

Issue: 3

Pages: 345-352

Print publication date: 01/03/2010

ISSN (print): 1473-7140

ISSN (electronic): 1744-8328


DOI: 10.1586/ERA.10.13

PubMed id: 20214516