Browse by author
Lookup NU author(s): Alison Costigan, Catherine Elliott, Dr Claire McDonald, Emerita Professor Julia Newton
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Objectives: To establish the relationship between the functional impairment experienced by Chronic fatigue syndrome (CFS) patients and the symptoms frequently experienced by those with CFS; specifically cognitive impairment, fatigue and orthostatic symptoms. Design: Cross sectional questionnaire survey. Setting: Specialist CFS Clinical Service. Subjects: Ninety-nine Fukuda diagnosed CFS and 64-matched controls. Main outcome measures: Symptom and functional assessment tools completed and returned by post included; PROMIS HAQ (Patient-Reported Outcomes Measurement Information System, Health Assessment Questionnaire), CFQ (Cognitive Failures Questionnaire), FIS (Fatigue Impact Scale) and OGS (Orthostatic Grading Scale) assessment tools. Results: CFS patients experience greater functional impairment than controls [mean (95% CI) PROMIS HAQ scores CFS 36 (31-42) vs. controls 6 (2-10); P<0.0001], especially in the functional domains of activities and reach. Poorer functional ability impairment is significantly associated with greater cognitive impairment (P = 0.0002, r = 0.4), fatigue (P<0.0001, r = 0.5) and orthostatic symptoms (P<0.0001, r = 0.6). However, only orthostatic symptoms (OGS) independently associated with functional impairment (β = 0.4, P = 0.01). Conclusions: Treatment of orthostatic symptoms in CFS has the potential to improve functional capacity and so improve quality of life. © The Author 2010. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved.
Author(s): Costigan A, Elliott C, McDonald C, Newton J
Publication type: Article
Publication status: Published
Journal: QJM
Year: 2010
Volume: 103
Issue: 8
Pages: 589-595
Print publication date: 09/06/2010
ISSN (print): 1460-2725
ISSN (electronic): 1460-2393
Publisher: Oxford University Press
URL: http://dx.doi.org/10.1093/qjmed/hcq094
DOI: 10.1093/qjmed/hcq094
Altmetrics provided by Altmetric
