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Cellular mechanisms of high frequency oscillations in epilepsy: on the diverse sources of pathological activities

Lookup NU author(s): Professor Andrew Trevelyan


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A major goal in epilepsy research is to understand the cellular basis of pathological forms of network oscillations, particularly those classified as high-frequency activity. What are the underlying mechanisms, and how do they arise? The topic of this review is the pattern of high-frequency oscillations that have been recorded in epileptic tissue, and how they might differ from physiological activity. We discuss recent experimental and clinical data with a major focus on the diverse sources of extracellular signals and the contribution of different neuronal populations, including GABAergic interneurons and glutamatergic principal cells.

Publication metadata

Author(s): Prida L, Trevelyan AJ

Publication type: Review

Publication status: Published

Journal: Epilepsy Research

Year: 2011

Volume: 97

Issue: 3

Pages: 308-317

Print publication date: 09/04/2011

ISSN (print): 0920-1211

ISSN (electronic): 1872-6844


DOI: 10.1016/j.eplepsyres.2011.02.009