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Ambient air pollution and congenital heart disease: A register-based study

Lookup NU author(s): Dr Payam Dadvand, Professor Judith Rankin, Professor Stephen Rushton, Professor Tanja Pless-Mulloli


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Maternal exposure to ambient air pollution has increasingly been linked to adverse pregnancy outcomes. The evidence linking this exposure to congenital anomalies is still limited and controversial. This case-control study investigated the association between maternal exposure to ambient particulate matter with aerodynamic diameter less than 10 mu m (PM10), sulfur dioxide (SO2), nitrogen dioxide, nitric oxide (NO), ozone (O-3), and carbon monoxide (CO) and the occurrence of congenital heart disease in the population of Northeast England (1993-2003). Each case and control was assigned weekly average (weeks 3-8 of pregnancy) of pollutant levels measured by the closest monitor to the mother's residential postcode. Using exposure as both continuous and categorical variables, logistic regression models were constructed to quantify the adjusted odds ratios of exposure to air pollutants and the occurrence of each outcome group. We found exposure to CO and NO to be associated with ventricular septal defect and cardiac septa malformations. CO was also associated with congenital pulmonary valve stenosis and NO with pooled cases of congenital heart disease and tetralogy of Fallot. Findings for SO2, O-3 and PM10 were less consistent. (C) 2011 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Dadvand P; Rankin J; Pless-Mulloli T; Rushton S

Publication type: Article

Publication status: Published

Journal: Environmental Research

Year: 2011

Volume: 111

Issue: 3

Pages: 435-441

Print publication date: 17/02/2011

ISSN (print): 0013-9351

ISSN (electronic): 1096-0953

Publisher: Academic Press


DOI: 10.1016/j.envres.2011.01.022


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