Browse by author
Lookup NU author(s): Professor Jarka Glassey
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Process analytical technology (PAT), the regulatory initiative for building in quality to pharmaceutical manufacturing, has a great potential for improving biopharmaceutical production. The recommended analytical tools for building in quality, multivariate data analysis, mechanistic modeling, novel models for interpretation of systems biology data and new sensor technologies for cellular states, are instrumental in exploiting this potential. Industrial biopharmaceutical production has gradually become dependent on large-scale processes using sensitive mammalian cell cultures. This further emphasizes the need for improved PAT solutions. We summarize recent progress in this area based on an expert workshop held at the 8(th) European Symposium on Biochemical Engineering Sciences (Bologna, 2010), and highlight new opportunities for exploiting PAT when applied in biopharmaceutical production. We conclude with recommendations for advancing PAT applications in the biopharmaceutical industry.
Author(s): Glassey J, Gernaey KV, Clemens C, Schulz TW, Oliveira R, Striedner G, Mandenius CF
Publication type: Article
Publication status: Published
Journal: Biotechnology Journal
Year: 2011
Volume: 6
Issue: 4
Pages: 369-377
Print publication date: 18/03/2011
ISSN (print): 1860-6768
ISSN (electronic): 1860-7314
Publisher: Wiley - VCH Verlag GmbH & Co. KGaA
URL: http://dx.doi.org/10.1002/biot.201000356
DOI: 10.1002/biot.201000356
Altmetrics provided by Altmetric
