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Lookup NU author(s): Professor Hermann Josef Vormoor
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This study describes the outcome of patients receiving haematopoietic stem cell transplantation (HSCT) to treat severe refractory autoimmune cytopenia. The registry of the European Group of Blood and Marrow Transplantation holds data on 36 patients receiving 38 transplants, the first transplant was autologous for 27 and allogeneic for nine patients. Patients had autoimmune haemolytic anaemia (autologous: 5; allogeneic: 2), Evans's syndrome (autologous: 2; allogeneic: 5); immune thrombocytopenia (autologous: 12), pure red cell aplasia (autologous: 4; allogeneic: 1), pure white cell aplasia (autologous: 1; allogeneic 1), or thrombotic thrombocytopenic purpura (autologous: 3). Patients had longstanding disease having failed multiple prior treatments. Among 26 evaluable patients mobilized for autologous HSCT, three died of treatment-related causes, one died of disease progression, seven were non-responders, six patients had transient responses and nine had continuous partial or complete remission. Of the seven evaluable patients receiving allogeneic HSCT, one died of treatment-related complications, one with transient response died of progressive disease and five had a continuous response. Autologous and allogeneic HSCT may induce a response in a subset of patients with autoimmune cytopenia of long duration albeit at the price of considerable toxicity.
Author(s): Passweg JR, Rabusin M, Musso M, Beguin Y, Cesaro S, Ehninger G, Espigado I, Iriondo A, Jost L, Koza V, Lenhoff S, Lisukov I, Locatelli F, Marmont A, Philippe P, Pilatrino C, Quartier P, Stary J, Veys P, Vormoor J, Wahlin A, Zintl F, Bocelli-Tyndall C, Tyndall A, Gratwohl A
Publication type: Article
Publication status: Published
Journal: British Journal of Haematology
Year: 2004
Volume: 125
Issue: 6
Pages: 749-755
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141
URL: http://dx.doi.org/10.1111/j.1365-2141.2004.04978.x
DOI: 10.1111/j.1365-2141.2004.04978.x
Notes: 0007-1048 (Print) Journal Article Multicenter Study
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