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Lookup NU author(s): Emeritus Professor Alan Craft, Dr Jennifer Kernahan, Dr Michael Reid, Dr Ronald Scott, Emeritus Professor Geoffrey Toms
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Children undergoing therapy for acute lymphoblastic leukaemia (ALL) are at increased risk of severe viral respiratory infection, and some find it difficult to terminate virus secretion. This increased severity may result from a defect in the mucosal immune response. To test this hypothesis, nasal immunoglobulin secretion and specific antiviral antibody responses to infection with respiratory syncytial (RS) virus in children with ALL have been compared with those in a normal age-matched comparison group. Children with leukaemia secreted normal levels of IgA and slightly raised IgM levels. IgG levels were depressed. Following RS virus infection, the majority of children with leukaemia secreted normal amounts of IgA and IgG nasal antibody and successfully cleared the virus. However, three of the 13 children studied made poor or undetectable nasal antibody responses, which correlated with their inability to clear the virus.
Author(s): Taylor CE, Craft AW, Kernahan J, Millman R, Reid MM, Scott R, Toms GL
Publication type: Article
Publication status: Published
Journal: Journal of Medical Virology
Year: 1990
Volume: 30
Issue: 4
Pages: 277-81
Print publication date: 01/04/1990
ISSN (print): 0146-6615
ISSN (electronic): 1096-9071
URL: http://dx.doi.org/10.1002/jmv.1890300409
DOI: 10.1002/jmv.1890300409
PubMed id: 2370522
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