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Local antibody production and respiratory syncytial virus infection in children with leukaemia

Lookup NU author(s): Emeritus Professor Alan Craft, Dr Jennifer Kernahan, Dr Michael Reid, Dr Ronald Scott, Professor Geoff Toms

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Abstract

Children undergoing therapy for acute lymphoblastic leukaemia (ALL) are at increased risk of severe viral respiratory infection, and some find it difficult to terminate virus secretion. This increased severity may result from a defect in the mucosal immune response. To test this hypothesis, nasal immunoglobulin secretion and specific antiviral antibody responses to infection with respiratory syncytial (RS) virus in children with ALL have been compared with those in a normal age-matched comparison group. Children with leukaemia secreted normal levels of IgA and slightly raised IgM levels. IgG levels were depressed. Following RS virus infection, the majority of children with leukaemia secreted normal amounts of IgA and IgG nasal antibody and successfully cleared the virus. However, three of the 13 children studied made poor or undetectable nasal antibody responses, which correlated with their inability to clear the virus.


Publication metadata

Author(s): Taylor CE, Craft AW, Kernahan J, Millman R, Reid MM, Scott R, Toms GL

Publication type: Article

Publication status: Published

Journal: Journal of Medical Virology

Year: 1990

Volume: 30

Issue: 4

Pages: 277-81

Print publication date: 01/04/1990

ISSN (print): 0146-6615

ISSN (electronic): 1096-9071

URL: http://dx.doi.org/10.1002/jmv.1890300409

DOI: 10.1002/jmv.1890300409

PubMed id: 2370522


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