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Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010

Lookup NU author(s): Dr Kanthimathin Sankar


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Successful treatment of gonorrhoea is the mainstay of public health control. Cefixime and ceftriaxone, highly active third generation cephalosporins, are today the recommended first-line agents in most countries and azithromycin is a second-line agent. However, there is increasing evidence of decreasing susceptibility and emergence of therapeutic failures. In this report two cases of clinical failure to cefixime are described, one of which additionally shows failure to azithromycin and selection of a less susceptible strain during treatment.

Publication metadata

Author(s): Ison CA, Hussey J, Sankar KN, Evans J, Alexander S

Publication type: Article

Publication status: Published

Journal: Eurosurveillance

Year: 2011

Volume: 16

Issue: 14

Pages: 7-10

Print publication date: 01/04/2011

ISSN (print): 1025-496X

ISSN (electronic): 1560-7917

Publisher: Centre Europeen pour la Surveillance Epidemiologique du SIDA