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Lookup NU author(s): Dr Gendie Lash,
Dr Judith Bulmer
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The most abundant immune cells in the uterine decidua around the time of implantation and early placental development are the uterine natural killer (uNK) cells. Altered numbers of uNK cells have been associated with several human reproductive disorders, including recurrent miscarriage, recurrent implantation failure, uterine fibroids, sporadic miscarriage, fetal growth restriction and preeclampsia. Understanding of the function of uNK cells in non-pregnant and pregnant endometrium is now increasing; the potential contribution of altered numbers and function of uNK cells to reproductive disorders is the focus of this review. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Author(s): Lash GE, Bulmer JN
Publication type: Review
Publication status: Published
Journal: Journal of Reproductive Immunology
Print publication date: 21/02/2011
ISSN (print): 0165-0378
ISSN (electronic): 1872-7603
Publisher: ELSEVIER IRELAND LTD