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Phosphate Transporters in Renal, Gastrointestinal, and Other Tissues

Lookup NU author(s): Dr Andreas Werner

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Abstract

Inorganic phosphate (Pi) is essential for all living organisms. Bound to organic molecules, Pi fulfills structural, metabolic, and signaling tasks. Therefore, cell growth and maintenance depends on efficient transport of Pi across cellular membranes into the intracellular space. Uptake of Pi requires energy because the substrate is transported against its electrochemical gradient. Till recently, 2 major families of physiologically relevant Pi-specific transporters have been identified: the solute carrier families Slc34 and Slc20. Interestingly, phylogenetic links can be detected between prokaryotic and eukaryotic transporters in both families. Because less complex model organisms are often instrumental in establishing paradigms for protein function in human beings, a brief assessment of Slc34 and Slc20 phylogeny is of interest. Crown Copyright 2011 Published by Elsevier Inc. on behalf of the National Kidney Foundation. All rights reserved.


Publication metadata

Author(s): Forster I, Hernando N, Sorribas V, Werner A

Publication type: Article

Publication status: Published

Journal: Advances in Chronic Kidney Disease

Year: 2011

Volume: 18

Issue: 2

Pages: 63-76

Print publication date: 12/03/2011

ISSN (print): 1548-5595

ISSN (electronic): 1548-5609

Publisher: WB Saunders Co.

URL: http://dx.doi.org/10.1053/j.ackd.2011.01.006

DOI: 10.1053/j.ackd.2011.01.006


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