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Amino Acid Catalysed Aldol Reactions in Cyclic Carbonate Solvents

Lookup NU author(s): Maria Morcillo, Professor Michael North, Dr Pedro Villuendas


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Ethylene and propylene carbonates are shown to be alternative polar aprotic solvents for cross-aldol reactions catalysed by the primary amino acids (S)-phenylalanine and (S)-tryptophan. In contrast to the corresponding proline-catalysed reactions, both enantiomers of these naturally occurring, primary amino acids are available at low cost. The optimal catalyst and solvent combination needs to be determined on a substrate by substrate basis.

Publication metadata

Author(s): Morcillo M, North M, Villuendas P

Publication type: Article

Publication status: Published

Journal: Synthesis

Year: 2011

Issue: 12

Pages: 1918-1925

Print publication date: 01/06/2011

ISSN (print): 0039-7881

ISSN (electronic): 1437-210X

Publisher: Georg Thieme Verlag


DOI: 10.1055/s-0030-1260038


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