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Parkinson's Disease: The Quintessential Neuropsychiatric Disorder

Lookup NU author(s): Professor David BurnORCiD

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Abstract

Although diagnosed by characteristic motor features, Parkinson's disease may be preceded, and is frequently accompanied by, a wide range of cognitive and neuropsychiatric features. In addition to the most commonly studied disorders of dementia, depression, and psychosis, other relatively common and clinically significant psychiatric complications include impulse control disorders, anxiety symptoms, disorders of sleep and wakefulness, and apathy. These problems may be underrecognized and are frequently under-treated. The emergent focus on nonmotor aspects of Parkinson's disease over the past quarter of a century is highlighted by a nonlinear increase in the number of articles published devoted to this topic. Although the development of newer antidepressants, atypical antipsychotics, and cholinesterase inhibitors in recent years has had a positive benefit on the management of these troublesome and distressing symptoms, responses are frequently suboptimal, and this remains an area of major unmet therapeutic need. (C) 2011 Movement Disorder Society

Publication metadata

Author(s): Weintraub D, Burn DJ

Publication type: Review

Publication status: Published

Journal: Movement Disorders

Year: 2011

Volume: 26

Issue: 6

Pages: 1022-1031

Print publication date: 27/05/2011

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: WILEY-BLACKWELL

URL: http://dx.doi.org/10.1002/mds.23664

DOI: 10.1002/mds.23664

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