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Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp NTK 935

Lookup NU author(s): Professor Alan Bull, Professor Michael Goodfellow


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Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3 beta and a weak antiproliferative activity against mouse fibroblast cells. The Journal of Antibiotics (2011) 64, 453-457; doi:10.1038/ja.2011.26; published online 20 April 2011

Publication metadata

Author(s): Nachtigall J, Schneider K, Bruntner C, Bull AT, Goodfellow M, Zinecker H, Imhoff JF, Nicholson G, Irran E, Sussmuth RD, Fiedler HP

Publication type: Article

Publication status: Published

Journal: Japanese Journal of Antibiotics

Year: 2011

Volume: 64

Issue: 6

Pages: 453-457

Print publication date: 01/06/2011

ISSN (print): 0021-8820

ISSN (electronic):

Publisher: Japan Antibiotics Research Association


DOI: 10.1038/ja.2011.26


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Funder referenceFunder name
Boehringer-Ingelheim Pharma GmbH (Biberach, Germany)
LSHM-CT-2004-005224European Commission