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Arteries become stiffer: Agreements between computer simulations and clinical measurements

Lookup NU author(s): Dr Ding Chang Zheng, Emeritus Professor Alan MurrayORCiD


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Arteries are naturally elastic and able to respond to different and changing pressure conditions. If these changes could be characterized and quantified, this would be clinically useful. This study investigated arterial property changes with changes in arterial pressure using computer simulations and clinical measurements. Three elastic tube models (ideal elastic model, stretching elastic model and physiological elastic model) were simulated to give the detailed relationships between arterial pressure (P) and arterial volume compliance (C) and pulse propagation time. Clinical measurements were performed in 8 subjects by positioning the arm to induce different arterial pressures. The changes in arm pulse propagation time, determined by subtracting ear pulse propagation time from finger pulse propagation time, were analyzed. Experimental results showed that both arm pulse propagation time and arterial volume compliance changes were inversely related to arterial pressure changes, which provided evidence that the characteristics of the physiological elastic model provide an understanding of how arterial properties change with arterial pressure.

Publication metadata

Author(s): Zheng D, Murray A

Editor(s): Murray, A

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Computers in Cardiology: 34th Annual Computers in Cardiology Conference

Year of Conference: 2007

Pages: 387-390

Date deposited: 09/07/2010

ISSN: 0276-6547

Publisher: IEEE Computer Society


DOI: 10.1109/CIC.2007.4745503

Library holdings: Search Newcastle University Library for this item

ISBN: 9781424425334