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Lookup NU author(s): Dr Ross Harrington,
Emeritus Professor Bill CleggORCiD
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Boc-protected (piperazin-1-ylmethyl)biaryls have been synthesised from (Boc-piperazin-1-ylmethyl) phenylboronic acid pinacol esters via a microwave-mediated Suzuki-Miyaura coupling with aryl bromides viz. 1-bromo-, 2-, 3- or 4-nitrobenzene or 2-bromo-5-nitropyridine. Judicial removal of the protecting group on the piperazine, or facile reduction of the nitro group on the biaryl system enabled the manipulation of two points of functionality in order to diversify the scope of the resulting biaryl library. (C) 2011 Elsevier Ltd. All rights reserved.
Author(s): Spencer J, Baltus CB, Press NJ, Harrington RW, Clegg W
Publication type: Article
Publication status: Published
Journal: Tetrahedron Letters
Print publication date: 20/05/2011
ISSN (print): 0040-4039
ISSN (electronic): 1873-3581
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