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Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism

Lookup NU author(s): Professor Colin Harwood, Dr Susanne Pohl


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Bacteria adapt to environmental stimuli by adjusting their transcriptomes in a complex manner, the full potential of which has yet to be established for any individual bacterial species. Here we report the transcriptomes of B. subtilis exposed to a wide range of environmental and nutritional conditions that it might encounter. Transcription units (TUs) were comprehensively mapped and 2935 promoters were grouped into regulons controlled by various RNA polymerase sigma factors accounting for ~66% of the observed variance in transcriptional activity. This global classification of promoters and detailed description of TUs revealed that a large proportion of the detected antisense RNAs arose from potentially spurious initiation by alternative sigma factors and from imperfect control of transcription termination. 0 0 1 122 700 Cell and Molecular Biosciences 5 1 821 14.0 Normal 0 false false false FR JA X-NONE

Publication metadata

Author(s): Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E, Hessling B, Kleijn RJ, Le Chat L, Lecointe F, Mäder U, Nicolas P, Piersma S, Rügheimer F, Becher D, Bessieres P, Bidnenko E, Denham EL, Dervyn E, Devine KM, Doherty G, Drulhe S, Felicori L, Fogg M, Goelzer A, Hansen A, Harwood CR, Hecker M, Hubner S, Hultschig C, Jarmer H, Klipp E, Leduc A, Lewis P, Molina F, Noirot P, Peres S, Pigeonneau N, Pohl S, Rasmussen S, Rinn B, Schaffer M, Schnidder J, Schwikowski B, Van Dijl JM, Veiga P, Walsh S, Wilkinson AJ, Stelling J, Aymerich S, Sauer U

Publication type: Article

Publication status: Published

Journal: Science

Year: 2012

Volume: 335

Issue: 6072

Pages: 1099-1103

Print publication date: 01/03/2012

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science


DOI: 10.1126/science.1206871


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Funder referenceFunder name
455646National Health and Medical Research Council
CG110055Department of Education, Science and Training
LSHG-CT-2006-037469European Commission