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Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study

Lookup NU author(s): Dr Ahmad Khundakar, Dr Christopher Morris, Arthur Oakley, Professor Alan ThomasORCiD


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Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.

Publication metadata

Author(s): Khundakar AA, Morris CM, Oakley AE, Thomas AJ

Publication type: Article

Publication status: Published

Journal: Psychiatry Research: Neuroimaging

Year: 2011

Volume: 194

Issue: 2

Pages: 184-189

Print publication date: 30/11/2011

ISSN (print): 0925-4927

ISSN (electronic): 1872-7506

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.pscychresns.2011.04.008

PubMed id: 21924875


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Funder referenceFunder name
Alzheimer's Research UK
Alzheimer's Society
Newcastle NIHR Biomedical Research Centre in Ageing and Age Related Diseases
G0400074UK Medical Research Council