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Lookup NU author(s): Dr Catherine Dotchin
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It was previously thought that the prevalence of Parkinson's disease (PD) in developing countries, and in particular sub-Saharan Africa (SSA), was lower than the rest of the world. The Hai PD prevalence project [1] diagnosed 32 patients (the majority previously undiagnosed and untreated) with PD from a population of 161,000, giving age standardised prevalence rates of 64 (men) and 20 (women)/100,000, respectively. Subsequently, drug treatment has been commenced for all surviving patients with annual follow up. The aim of the study was to document response to treatment, development of side effects, progression of disease and feasibility and sustainability of supplying medication to patients in rural Tanzania. Eleven patients died before the start of medication, and a further four during follow up. One patient moved away from the study area. At the end of 3 years of treatment, 16 patients were surviving. Only one stopped medication due to side effects (dyskinesia). At 3 years, 9/16 experienced wearing off and a further three had dyskinesias. Non motor symptoms were a problem at initial assessment [2] and continued to be a problem for many of the patients. We have shown that it is possible to find, treat and follow up patients with PD in a rural sub-Saharan African setting. Availability of affordable medication locally is a major issue. Acknowledging that movement disorders and neurological diseases in general are an issue in this setting is important to drive education and training, and for allocation of funding from health care providers in SSA.
Author(s): Dotchin C, Jusabani A, Walker R
Publication type: Article
Publication status: Published
Journal: Journal of Neurology
Year: 2011
Volume: 258
Issue: 9
Pages: 1649-1656
Print publication date: 27/03/2011
ISSN (print): 0340-5354
ISSN (electronic): 1432-1459
Publisher: Dr. Dietrich Steinkopff Verlag
URL: http://dx.doi.org/10.1007/s00415-011-5988-y
DOI: 10.1007/s00415-011-5988-y
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