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Soluble but not platelet P-selectin correlates with spontaneous platelet aggregation: a pilot study

Lookup NU author(s): Dr Jonathan Smout, Dr Alexander Dyker, Professor Gary Ford, Professor Gerard Stansby


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BACKGROUND: P-selectin (PS) is a marker of platelet activation measured on the platelet surface as platelet PS (pPS) or in serum as soluble PS (sPS). Controversy remains over the exact relationship between sPS, pPS, and other markers such as spontaneous platelet aggregation (SPA). OBJECTIVE: To investigate correlations between pPS, sPS, and SPA in patients with peripheral arterial disease. METHODS: SPA, pPS, and sPS levels were measured in venous blood sampled from patients following intermittent claudication (n = 18) or an acute stroke (n = 18). RESULTS: SPA and sPS correlated significantly in the claudicants (Pearson correlation coefficient, r = 0.661; P = .0020) and stroke patients (r = 0.514; P = .020). No significant correlation was identified between pPS and SPA, or sPS and pPS. CONCLUSIONS: The 2 methods of assessing PS are not comparable. Although pPS is accepted as a platelet activation marker, sPS may be a better indicator of aggregation represented by SPA.

Publication metadata

Author(s): Cleanthis M, Smout J, Bhattacharya V, Ashour H, Dyker A, Ford GA, Mikhailidis DP, Stansby GP

Publication type: Article

Publication status: Published

Journal: Clinical and Applied Thrombosis/Hemostasis

Year: 2008

Volume: 14

Issue: 2

Pages: 227-233

ISSN (print): 1076-0296

ISSN (electronic): 1938-2723

Publisher: Sage Publications, Inc.


DOI: 10.1177/1076029607305915

Notes: Journal Article United States official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis


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