Toggle Main Menu Toggle Search

Open Access padlockePrints

Dynamic Covalent Single-Chain Polymer Nanoparticles

Lookup NU author(s): Dr Ben Murray, Dr David Fulton


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by the formation of dynamic covalent bonds. Linear chains of poly(vinylbenzaldehyde) were intramolecularly cross-linked through the formation of dynamic covalent acylhydrazone bonds with a bis-hydrazide cross-linker. The cross-linking density was shown to be controlled by the amount of crosslinker used. The resulting single polymer chain nanoparticles were then adorned through reaction of their remaining aldehyde units with a series of monoacyl hydrazides or alkoxyamines. Alternatively, the linear polymer chains could be fully adorned by reaction of their aldehyde units with the monoacyl hydrazides and then intramolecularly cross-linked through exchange reactions with the bis-hydrazide cross-linker. Both approaches proved effective routes to prepare single-chain polymer nanoparticles possessing high functional density.

Publication metadata

Author(s): Murray BS, Fulton DA

Publication type: Article

Publication status: Published

Journal: Macromolecules

Year: 2011

Volume: 44

Issue: 18

Pages: 7242-7252

Print publication date: 02/09/2011

ISSN (print): 0024-9297

ISSN (electronic): 1520-5835

Publisher: American Chemical Society


DOI: 10.1021/ma201331f


Altmetrics provided by Altmetric