ePrints

Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment

Lookup NU author(s): Chinyere Okoro, Professor Alan Bull, Professor Michael Goodfellow

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5 ''-dihydro-hygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

Publication metadata

Author(s): Rateb ME, Houssen WE, Harrison WTA, Deng H, Okoro CK, Asenjo JA, Andrews BA, Bull AT, Goodfellow M, Ebel R, Jaspars M

Publication type: Article

Publication status: Published

Journal: Journal of Natural Products

Year: 2011

Volume: 74

Issue: 9

Pages: 1965-1971

Print publication date: 31/08/2011

ISSN (print): 0163-3864

ISSN (electronic): 1520-6025

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/np200470u

DOI: 10.1021/np200470u

Altmetrics

Funding

Share