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Lookup NU author(s): Chinyere Okoro,
Professor Alan Bull,
Professor Michael Goodfellow
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The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5 ''-dihydro-hygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
Author(s): Rateb ME, Houssen WE, Harrison WTA, Deng H, Okoro CK, Asenjo JA, Andrews BA, Bull AT, Goodfellow M, Ebel R, Jaspars M
Publication type: Article
Publication status: Published
Journal: Journal of Natural Products
Print publication date: 31/08/2011
ISSN (print): 0163-3864
ISSN (electronic): 1520-6025
Publisher: American Chemical Society
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