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Functional domains and motifs of bacterial type III effector proteins and their roles in infection

Lookup NU author(s): Dr Paul Dean

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Abstract

A key feature of the virulence of many bacterial pathogens is the ability to deliver effector proteins into eukaryotic cells via a dedicated type three secretion system (T3SS). Many bacterial pathogens, including species of Chlamydia, Xanthomonas, Pseudomonas, Ralstonia, Shigella, Salmonella, Escherichia and Yersinia, depend on the T3SS to cause disease. T3SS effectors constitute a large and diverse group of virulence proteins that mimic eukaryotic proteins in structure and function. A salient feature of bacterial effectors is their modular architecture, comprising domains or motifs that confer an array of subversive functions within the eukaryotic cell. These domains/motifs therefore represent a fascinating repertoire of molecular determinants with important roles during infection. This review provides a snapshot of our current understanding of bacterial effector domains and motifs where a defined role in infection has been demonstrated.

Publication metadata

Author(s): Dean P

Publication type: Review

Publication status: Published

Journal: FEMS Microbiology Reviews

Year: 2011

Volume: 35

Issue: 6

Pages: 1100-1125

Print publication date: 18/05/2011

ISSN (print): 0168-6445

ISSN (electronic): 1574-6976

Publisher: WILEY-BLACKWELL

URL: http://dx.doi.org/10.1111/j.1574-6976.2011.00271.x

DOI: 10.1111/j.1574-6976.2011.00271.x

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