Toggle Main Menu Toggle Search

Open Access padlockePrints

Fitting the two-stage model of carcinogenesis to nested case-control data on the Colorado Plateau uranium miners: dependence on data assumptions

Lookup NU author(s): Dr Colin Muirhead


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


This paper investigates some problems with the Colorado Plateau uranium miners cohort when fitting the mechanistic model of carcinogenesis of Moolgavkar et al. (MVK model) to nested case-control data for lung cancers. The influence of data for hard rock mining and work histories on the model fitting is examined and found to be highly influential. The question of selecting the most appropriate number of controls per case is also considered. Analyses were carried out assuming that the hard rock mining exposure occurred prior to all other work histories and that miners received no exposure between work histories. The use of less than 15 controls per case was found to seriously restrict the quality of fit of the models. The best fitting, most reliable model contained linear effects of radon exposure on the first mutation rate, the rate of differentiation, and the rate of death of the intermediate cells. An effect of smoking on the growth of the intermediate cells was also included in the model. It is concluded that owing to the complexity of the MVK model and the limited amount of information in this dataset, the reliability of the Colorado Plateau dataset for fitting this type of model, particularly in a case-control format, is questionable.

Publication metadata

Author(s): Haylock RGE, Muirhead CR

Publication type: Article

Publication status: Published

Journal: Radiation and Environmental Biophysics

Year: 2004

Volume: 42

Issue: 4

Pages: 257-263

ISSN (print): 0301-634X

ISSN (electronic): 1432-2099

Publisher: Springer


DOI: 10.1007/s00411-003-0213-8


Altmetrics provided by Altmetric