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Lookup NU author(s): Dr Elizabeth Veal,
Dr Alison Day
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Increases in hydrogen peroxide can initiate protective responses to limit or repair oxidative damage. However, hydrogen peroxide signals also fine-tune responses to growth factors and cytokines to control cell division,differentiation, and migration. Here we discuss some of the mechanisms by which hydrogen peroxide is sensed and utilized as a signaling molecule to regulate diverse biological processes. We also discuss how the localization and levels of hydrogen peroxide, antioxidants, and the cellular metal composition together influence the nature of the response.
Author(s): Veal EA, Day AM
Publication type: Editorial
Publication status: Published
Journal: Antioxidants and Redox Signaling
Print publication date: 25/05/2011
ISSN (print): 1523-0864
ISSN (electronic): 1557-7716
Publisher: Mary Ann Liebert, Inc. Publishers