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Real-Time FPGA-Based Multichannel Spike Sorting Using Hebbian Eigenfilters

Lookup NU author(s): Bo Yu, Dr Terrence Mak, Dr Fei Xia, Professor Alex Yakovlev, Dr Yudong Sun


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Real-time multi-channel neuronal signal recordinghas spawned broad applications in neuro-prostheses and neurorehabilitation.Detecting and discriminating neuronal spikes frommultiple spike trains in real-time require significant computationalefforts and present major challenges for hardwaredesign in terms of hardware area and power consumption. Thispaper presents a Hebbian eigenfilter spike sorting algorithm,in which principal components analysis (PCA) is conductedthrough Hebbian learning. The eigenfilter eliminates the needof computationally expensive covariance analysis and eigenvaluedecomposition in traditional PCA algorithms and, most importantly,is amenable to low cost hardware implementation. Scalableand efficient hardware architectures for real-time multi-channelspike sorting are also presented. In addition, folding techniquesfor hardware sharing are proposed for better utilization ofcomputing resources among multiple channels. The throughput,accuracy and power consumption of our Hebbian eigenfilter arethoroughly evaluated through synthetic and real spike trains.The proposed Hebbian eigenfilter technique enables real-timemulti-channel spike sorting, and leads the way towards the nextgeneration of motor and cognitive neuro-prosthetic devices.

Publication metadata

Author(s): Yu B, Mak T, Li X, Xia F, Yakovlev A, Sun Y, Poon C

Publication type: Article

Publication status: Published

Journal: IEEE Journal on Emerging and Selected Topics in Circuits and Systems (JETCAS)

Year: 2012

Volume: 1

Issue: 4

Pages: 502-515

Print publication date: 30/01/2012

ISSN (print): 2156-3357

ISSN (electronic): 2156-3365

Publisher: IEEE


DOI: 10.1109/JETCAS.2012.2183430


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Funder referenceFunder name
4112029Beijing Natural Science Foundation
61006021National Natural Science Foundation of China
EP/E044662/1EPSRC Grant
HL067966U. S. National Institutes of Health
R028241U. S. National Institutes of Health