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Assessment of glomerular filtration rate in pregnancy using the MDRD formula

Lookup NU author(s): Dr Marie Smith, Dr Michael Ward, Emeritus Professor John Davison


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It is now recommended practice to use estimated glomerular filtration rate (eGFR) values to screen for and monitor chronic renal disease. The most frequently used formula in the general population is that described following the Modification of Diet in Renal Disease (MDRD) study whereby serum creatinine is adjusted for age, gender and race. This study evaluates the performance of the MDRD formula in pregnancy by comparing eGFR with measured values obtained by inulin clearance studies in early and late normal pregnancy and in pregnancies complicated by renal disease or preeclampsia. Our results indicate that in all situations, MDRD substantially underestimates glomerular filtration rate during pregnancy and cannot be recommended for use in clinical practice.

Publication metadata

Author(s): Smith MC, Moran P, Ward MK, Davison JM

Publication type: Article

Publication status: Published

Journal: British Journal of Obstetrics and Gynaecology

Year: 2008

Volume: 115

Issue: 1

Pages: 109-112

Print publication date: 26/10/2007

ISSN (print): 0140-7686

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1471-0528.2007.01529.x


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