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The role of the Eph-ephrin signalling system in the regulation of developmental patterning

Lookup NU author(s): Dr Malcolm Coulthard, Dr Matthew Down, Dr Bethan Evans


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The Eph and ephrin system, consisting of fourteen Eph receptor tyrosine kinase proteins and nine ephrin membrane proteins in vertebrates, has been implicated in the regulation of many critical events during development. Binding of cell surface Eph and ephrin proteins results in bi-directional signals, which regulate the cytoskeletal, adhesive and motile properties of the interacting cells. Through these signals Eph and ephrin proteins are involved in early embryonic cell movements, which establish the germ layers, cell movements involved in formation of tissue boundaries and the pathfinding of axons. This review focuses on two vertebrate models, the zebrafish and mouse, in which experimental perturbation of Eph and/or ephrin expression in vivo have provided important insights into the role and functioning of the Eph/ephrin system.

Publication metadata

Author(s): Coulthard MG, Duffy S, Down M, Evans B, Power M, Smith F, Stylianou C, Kleikamp S, Oates A, Lackmann M, Burns GF, Boyd AW

Publication type: Review

Publication status: Published

Journal: International Journal of Developmental Biology

Year: 2002

Volume: 46

Issue: 4

Pages: 375-384

Print publication date: 01/01/2002

ISSN (print): 0214-6282

ISSN (electronic): 1696-3547

Publisher: U B C PRESS