Toggle Main Menu Toggle Search

Open Access padlockePrints

Vitamin D Status in Paediatric Patients With Cancer

Lookup NU author(s): Dr Akash Sinha, Dr Peter Avery, Professor Simon BaileyORCiD, Professor Timothy Cheetham


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background. Children with malignant disease are at increased risk of bone disorders and cardiovascular disease. Vitamin D status may influence this risk and so we assessed vitamin D levels in children with malignant disease undergoing active treatment or surveillance post-therapy. Procedure. This was an outpatient-based cross-sectional study of 61 children with a history of malignancy (median age 11.1 years; range 1.5-24.4 years) and 60 control subjects (median age 8.4 years; range 0.2-18.0 years) attending hospital for the management of non-malignant disorders. Serum vitamin D (25-OH-D), parathormone levels and bone biochemistry were determined. Vitamin D status and its relationship to age, sex, ethnicity, time of sampling and presence of malignant disease was determined. Results. Vitamin D status was suboptimal in 62% of cases (25-OH-D < 50 nmol/L [20 ng/ml]). Vitamin D deficiency (25-OH-D < 25 nmol/L [10 ng/ml]) was more common in children with malignant disease than controls (21.3% vs. 3.3%; P = 0.013). Month of sampling (P < 0.001), ethnicity (P < 0.001), older age (P = 0.011), and history of malignancy (P = 0.012) were associated with a poorer vitamin D status. Conclusions. Vitamin D levels [25-OH-D] are lower in survivors of childhood cancer in comparison to control children with the majority either insufficient or deficient. Assessment and adequate replacement of vitamin D status may be of particular value in this group of children. Pediatr Blood Cancer 2011;57:594-598. (C) 2011 Wiley-Liss, Inc.

Publication metadata

Author(s): Sinha A, Avery P, Turner S, Bailey S, Cheetham T

Publication type: Article

Publication status: Published

Journal: Pediatric Blood & Cancer

Year: 2011

Volume: 57

Issue: 4

Pages: 594-598

Print publication date: 03/02/2011

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/pbc.22963


Altmetrics provided by Altmetric